Immunai has curated high-quality public single-cell RNA-Seq (scRNA-Seq) studies from a wide spectrum of different research areas of biopharmaceutical research. In line with the curation of bulk-tissue data, the curation of scRNA-seq data is characterized by the use of controlled vocabularies, peer-reviewing by domain experts and stringent quality control. In addition, state-of-the-art methods for cell clustering, batch effect removal and cell-type identification and annotation were applied to provide researchers with consistent and analysis-ready data compendia. Our compendia consist of human and mouse scRNA-Seq data and are available in different data formats to be explored with your prefered analysis tools.

GENEVESTIGATOR^® now enables the analysis of deeply curated single-cell RNA-Seq (scRNA-Seq) data from public repositories using its user-friendly visualization tools. Its unique collections of high quality and deeply curated data enable researchers to understand molecular mechanisms of development and disease, and to uncover cellular heterogeneity in normal and diseased tissue. The consistent processing, curation, clustering, cell type identification and harmonization of studies within compendia allow the user to save time and resources and to focus on addressing exciting questions spanning different therapeutic areas.

Get inspired by some key applications for curated scRNA-Seq gene expression data:

1. Obtain high-resolution views of single-cell heterogeneity on a global scale
2. Reveal complex and rare cell populations
3. Track the trajectories of distinct cell lineages in development or in response to stimuli
4. Uncover regulatory relationships on the cell-type level for improved target discovery
5. Identify cell-type specific disease associations for biomarker development
6. Unbiased data-driven decision making

Curated compendia

Compendia consist of human and mouse scRNA-Seq data and are available in different data formats to be explored with your prefered analysis tools.
Single-cell RNA-Seq studies in GENEVESTIGATOR^® are available as extra data subscriptions for chosen focus areas. Currently, data are available for the following areas, each containing baseline seminal studies and more specific studies:

1. Cardiovascular System
2. Digestive and Endocrine Systems
3. Immune System
4. Nervous System
5. Oncology
6. Reproductive and Renal Systems
7. Respiratory System
8. Various Systems (currently with data from osteoarthritis, dermatology and others)

To get a more detailed overview of single-cell studies in these areas or in another area of interest, please write to info@nebion.com.

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