Recently, Pfaender et al. (2020) reported that the lymphocyte antigen 6 complex, locus E (LY6E) protein potently restricts cellular infection by multiple coronaviruses, including SARS-CoV-2. Using GENEVESTIGATOR® across multiple compendia and platforms, we screened thousands of experimental conditions to study the gene expression regulation of LY6E. Here are some of the most significant effects we found:
| Condition | Description | Fold-change |
|---|---|---|
| IFNb-1a (Avonex) | HS-01577 / Neutrophils isolated from peripheral blood samples of patients with multiple sclerosis 24 hours after the first treatment with IFNb-1A (Avonex). Control: patients before treatment. | 137x upregulation |
| Influenza | HS-03257 / Plasmacytoid dendritic cells isolated from the blood of healthy donors were treated 24h with influenza A/PR/8/34 (H1N1) virus. Control: Plasmacytoid dendritic cells isolated from healthy donors. | 20x upregulation |
| Lupus | LY6E is strongly upregulated in several SLE case-control studies | 10-40x upregulation |
| IFM-a2b | HS-00230 / Immature dendritic cells treated with 1000 u/ml of IFN-a2b. Control: without treatment | 7x upregulation |
| Brefeldin A | HS-01936 / LY6E is downregulated in response to Brefeldin A treatment. | 6x downregulation |
| Sepsis | HS-01577 / LY6E is strongly downregulated in neutrophils isolated from peripheral blood samples of patients with sepsis as compared to healthy subjects. | 200x downregulation |
Table: Conditions causing an up- or downregulation of the LY6E gene, as identified using the Perturbations tool in GENEVESTIGATOR®.