Host transcriptional response to SARS-CoV-2

08 Jul 2020

Response to SARS-CoV-2

Explore transcriptional response of host cells to infection with the novel SARS-Cov-2 virus in GENEVESTIGATOR®! The example below shows a comparison of SARS-Cov-2 infected vs. uninfected primary cells from a recently published study (10.1016/j.cell.2020.04.026). The observed up-regulation of CCL20, IL-6, CXCL8 and other pro-inflammatory cytokines indicates that the infected cells elicit a strong chemotactic and inflammatory response.

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Figure: Differential expression analysis of SARS-Cov-2 infected vs. uninfected primary human epithelial cells. GENEVESTIGATOR® volcano plot showing differentially expressed genes (up-regulated in red, down-regulated in green; top-20 up-regulated gene names shown)..