Recently, Pfaender et al. (2020) reported that the lymphocyte antigen 6 complex, locus E (LY6E) protein potently restricts cellular infection by multiple coronaviruses, including SARS-CoV-2.
Under the hypothesis that the expression level of the ACE2 receptor correlates with the degree of infection by the virus, we screened over 10,000 experimental conditions to identify those causing a strong up- or down-regulation of ACE2.
COVID-19 is not only a respiratory disease, it affects multiple organs and also the immune system.