Blog Post
Response to SARS-CoV-2
Explore transcriptional response of host cells to infection with the novel SARS-Cov-2 virus in GENEVESTIGATOR®!
Blog Post
Priming protease Furin
SARS-Cov-2 differs from closely related coronaviruses (including SARS-Cov) in the sequence of its spike protein, among other differences.
Blog Post
Regulation of LY6E
Recently, Pfaender et al. (2020) reported that the lymphocyte antigen 6 complex, locus E (LY6E) protein potently restricts cellular infection by multiple coronaviruses, including SARS-CoV-2.
Blog Post
Conditions regulating ACE2
Under the hypothesis that the expression level of the ACE2 receptor correlates with the degree of infection by the virus, we screened over 10,000 experimental conditions to identify those causing a strong up- or down-regulation of ACE2.
Blog Post
ACE2 versus TMPRSS2
To infect human cells, the SARS-CoV-2 receptor requires the presence of at least the ACE2 receptor (angiotensin-converting enzyme 2) and of the priming protease TMPRSS2 (transmembrane serine protease 2).
Blog Post
Tissue expression of ACE2
COVID-19 is not only a respiratory disease, it affects multiple organs and also the immune system.